Could cervical cancer be eliminated by vaccination against human papillomavirus (HPV) infection, even in low-income countries, where it is the major cancer type?
HPV vaccines, which have been available since 2006, are a proven, safe, and effective means of reducing cervical cancer rates.
Future challenges are to extend coverage and achieve universal implementation.
- World Health Organization (2013). Essential Training Package for HPV vaccine introduction for countries introducing Cervarix™ 2 dose vial. Available in English and French.
- Centers for Disease Control and Prevention (2019). Human Papillomavirus (HPV), For Healthcare Professionals. On-line toolkit to help professionals communicate effectively with parents about HPV vaccination.
- World Health Organization, Immunization, Vaccines and Biologicals, Human papillomavirus vaccines (HPV) (webpage)
- Baussano I, et al. (2020). Prevalence of human papillomavirus and estimation of human papillomavirus vaccine effectiveness in Thimphu, Bhutan, in 2011–2012 and 2018.Annals of Internal Medicine 173(11): 888-894.
- Brisson M, et al. (2020). Impact of HPV vaccination and cervical screening on cervical cancer elimination: a comparative modelling analysis in 78 low-income and lower-middle-income countries.The Lancet 395(10224): 575-590.
- Brotherton JM (2018). Human papillomavirus vaccination update: nonavalent vaccine and the two-dose schedule.Aust J Gen Pract 47(7): 417-421.
- Drolet M, et al. (2019). Population-level impact and herd effects following the introduction of human papillomavirus vaccination programmes: updated systematic review and meta-analysis.Lancet 394(10197): 497-509.
- Hall MT, et al. (2019). The projected timeframe until cervical cancer elimination in Australia: a modelling study.Lancet Public Health 4(1): E19-E27.
- Joura EA, et al. (2015). A 9-valent HPV vaccine against infection and intraepithelial neoplasia in women.New England Journal of Medicine 372(8): 711-723.
- Lehtinen M, Dillner J (2013). Clinical trials of human papillomavirus vaccines and beyond.Nature Reviews Clinical Oncology 10(7): 400-410.
- Phillips A, et al. (2020). Adverse events following HPV vaccination: 11 years of surveillance in Australia.Vaccine 38(38): 6038-6046.
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